Endocrine Abstracts

Adrenal insufficiency, characterised by inadequate cortisol production, significantly impacts quality of life and overall health. Current treatment primarily involves hydrocortisone replacement. However, dosing challenges and risk of adverse cardiovascular complications persist with this therapy. Consequently, there is a pressing need for safer glucocorticoid replacement options to mitigate the cardiometabolic toxicity, while effectively managing adrenal insufficiency. Prelimi...

Introduction: Adrenal scintigraphy using [131I]6ß-iodomethyl-19-norcholesterol has been available since 1975, primarily for the diagnosis of hyperaldosteronism helping to distinguish between unilateral adenoma and bilateral hyperplasia. First line treatment of ACTH-independent form of Cushing syndrome is surgery after localization of the cortisol-producing adrenal tumour.Case report: A 31-year-old woman has been referred to the endocrine ...

Introduction: Primary hyperparathyroidism (PHPT) is one of the most common causes of non-neoplastic hypercalcemia with characteristically increased or inappropriately normal plasma parathyroid hormone (PTH) levels. Hypercalcemia is also a significant feature of patients with multiple myeloma (MM), and a pathogenetic link is presumed between the two diseases, strengthened by preclinical data. Only limited number of case reports of concomitant PHPT and MM are available in the li...

Background: Hypothyroidism is one of the most frequent conditions in endocrinology. Despite of that fact, indications for treatment differ among specialists in Spain.Aims: To identify attitudes of Spanish endocrinologists in the use of levothyroxine (LT4) therapy and the management of hypothyroidism.Methods: The members of the Sociedad Española de Endocrinología y Nutrición (Spanish Society of Endocrinology ...

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

Background: The standard, lifelong therapy of phenylketonuria (PKU) is natural protein-restricted diet completed with Phenylalanine (Phe)-free L-amino acid mixtures that provide the daily necessary micronutrients, such as iodine and selenium. Our main objective in this study was to assess the iodine and selenium status of patients with PKU, based on their adherence to the low-Phe diet, compared to a healthy control group. Secondly, we aimed to asses whether adherence to therap...

Background: Few effective medical treatment options are available for adrenocortical carcinoma (ACC). Intensive efforts are therefore going on for exploring novel pathways and treatment targets.Objective: To perform a proteomic and pathway analysis on a 9-cisRA (9-cis retinoic acid) and mitotane-treated ACC xenograft model.Methods: 43 male SCID mice xenografted with NCI-H295R cells were treated in four groups (i. control, ii. 5 mg/...

: Hypothalamic regulation of pituitary adrenocorticotropic hormone (ACTH) secretion switches to dopamine (DA) with a parallel loss of DAerg control of alpha-melanocyte-stimulating hormone (α-MSH) release in lactating dams. It has been also shown that dephosphorylation/inactivation of tyrosine hydroxylase (TH) in terminals of DA neurons at the median eminence is required not only for suckling-induced PRL release but also for ACTH responses. The aim of the present study was...

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...